Wolfram syndrome is a rare, severe, autosomal recessive neurodegenerative disease that progressively affects several organs. The disease is characterized by the combination of diabetes insipidus, diabetes mellitus, optic atrophy, deafness, cerebral atrophy and progressive neurodegeneration.

The first symptoms usually appear during the first decade of life, and the disease progresses towards central respiratory failure caused by massive cerebral atrophy. The outcome of the disease is fatal.

Affecting nearly 30,000 people worldwide, there is currently no specific treatment for this disease.

Alzheimer’s disease is a neurodegenerative disorder characterized by progressive and irreversible damage to brain function, with a slow but inexorable loss of nerve cells, or neurons. The disease develops insidiously over many years, without any apparent clinical signs. When they do occur, the disorders in patients are varied and include loss of cognitive functions (memory, language, reasoning), motor functions (movements, balance, everyday gestures), and behavioral functions (inappropriate behavior in a given situation, autonomy). These disorders can change over time in the same person, but the progression is irreversible. Brain functions gradually decline, changing the family and social lives of those affected and causing a severe loss of independence

Alzheimer’s disease affects more than 900,000 people in France each year, with more than 225,000 new cases, the symptoms of which vary and the frequency of which increases with age. Pathological signs found in patients’ brains include senile plaques, neurofibrillary tangles, and generalized neuroinflammation, which the latest therapeutic treatments aim to reduce.